InDesign used to be my program of choice for design issues, but since it is super-slow on my MacIntel I have been looking for another solution. OmniGraffle Pro has been my main tool for creating small vector graphics for a while, and I gave it a chance to make a full poster. I am very happy with the work flow and the end result looks great. It handles pictures effortlessly (although I miss some simple photo tweaking utilities and cropping) and the graphics look very crisp even in a large format. Not really sure why I didn’t try this a long time ago.